Cardiovascular-protective effect of tadalafil in the treatment of erectile dysfunction

Cialis is meant to affect your cardiovascular system. When you get an erection, the arteries in your penis relax and open up, allowing more blood flow in. At the same time, the veins in that area close up. Once blood is in the penis, the pressure traps it within your corpora cavernosa (a.k.a. your erectile tissue). This is what makes your penis expand.

[Cardiovascular-protective effect of tadalafil in the treatment of erectile dysfunction]

The enzyme phosphodiesterase-5 (PDE-5), widely distributed in the heart, smooth muscle, and blood vessels, catalyzes the hydrolysis of cyclic guanosine monophosphate (cGMP), a potent vasodilator, and is also a nitric oxide (NO) donor. Tadalafil is the first PDE 5 inhibitor approved by FDA for the treatment of ED. Recent studies have shown several pleiotropic beneficial effects of PDE-5 inhibitors in patients with cardiovascular diseases (coronary heart disease, hypertension, heart failure, and pulmonary arterial hypertension) and diabetes mellitus. It has been demonstrated that tadalafil can not only improve sexual function, but also elevate the endothelial cell-derived NO level, activate protein kinase A, upregulate the intracellular Ca2+ concentration, and improve hemodynamic indexes. Thus, the PDE-5 inhibitor tadalafil, with its cardiovascular-protective effect, can be a therapeutic option for the treatment of ED patients with cardiovascular disease.

Cialis Heart Medication

Cardiovascular-protective effect of tadalafil in the treatment of erectile dysfunction

[Cardiovascular-protective effect of tadalafil in the treatment of erectile dysfunction]

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