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Final treatment plans are shared decisions determined with your clinician after this online assessment. Always read the leaflet and treatment plan.

You still need to be sexually aroused for it to work, so everything needs to be exciting. You’ve got this.

Take a pill an hour before you want to have sex. Tadalafil starts to work within 30-60 mins and maximum erection potential happens around the 1 hour mark.

Tadalafil can last up to 36 hours. So absolutely no need to rush. You’ve got plenty of time.

Erections really aren’t that easy. For a lot of men. About 40% of men have erection difficulties by age 40. But help is here. Tadalafil is one option for men with E.D. and lasts for up to 36 hours. Whatever the cause, it helps for the vast majority of men.

Hypotension (blood pressure <90/50 mmHg), recent stroke or heart attack

Is Tadalafil the same as Cialis?

Yes, Tadalafil is exactly the same as Cialis. Tadalafil is the active ingredient in Cialis, and the only difference is the brand name and the cost. You will always need a prescription for Tadalafil or Cialis in the UK, so be wary of counterfeit Cialis being sold on the internet. If you’re buying ED medication online, look for the MHRA Distance-Selling Logo (like we have at Manual) to be sure you can trust the source.

How does Cialis (Tadalafil) work?

Tadalafil works by inhibiting the PDE5 enzyme, which is responsible for smooth muscle contraction within the blood vessels. Taking Tadalafil enables the blood vessels in the penis to expand, meaning that blood flow is improved in the place it matters, when you need it most. Tadalafil makes it easier to achieve firmer erections – but only when you’re also naturally aroused..

How long does Cialis (Tadalafil) last?

Tadalafil lasts for up to 36 hours – giving you a bit more spontaneity in your love life than Sildenafil (Viagra). That’s why they call Tadalafil the “weekend pill”. With its long-lasting effects, Tadalafil can be very handy for a romantic trip away – and also for men who anticipate more regular sex without wanting to pop a pill every time they want to get it on.

How long does it take for Tadalafil to work?

Tadalafil can start to work in 30 minutes, which is one of its major benefits as it can be somewhat quicker than other erectile dysfunction medications. It is also unaffected by food intake, unlike the common alternative ED drug – Sildenafil (Viagra), so this is another reason why Tadalafil is so popular. You will need to be sexually stimulated for Tadalafil to work, but don’t worry, you have plenty of time

Is Tadalafil right for me?

Tadalafil is right for you if you’re looking for more spontaneity than Sildenafil can provide, or if you’ve experienced unwanted side effects from Sildenafil. A study has shown that it is more widely tolerated than many other PDE5 enzyme inhibitors. Tadalafil may also work better for those men who didn’t see the desired effects after taking Sildenafil

We’ll ask you a couple of quick medical questions. Tick the boxes and a clinician will review your answers and issue you a prescription.

Your selected treatment will be delivered for free, with discreet packaging and instructions on how to use it.

Chat with a medical expert whenever you need. On the phone or via email. With support throughout your treatment.

Enabling the mission of revolutionising how men approach health, they are at the core of the men’s wellness platform. Meet our team.

Speak with one of our clinicians and get personalised advice.

Monday to Friday 9am-4:30pm

Curated by Dr. Earim Chaudry, MBBS, Chief Medical Officer

Here at Manual, we give comprehensive guidance about all things ED. Our clinicians are here to help with expert healthcare advice, so get in touch if you have any questions that aren’t answered below.

How can Manual help treat my ED?

The many causes of regular ED can be both psychological or physiological. In lots of patients, it can be a combination of different factors, so we advise having a checkup by a doctor if you’re concerned. If you choose Tadalafil, you’ll be in good hands with us. At Manual, we only work with accredited trustworthy suppliers. You’ll receive your medication from the registered Manual Pharmacy, and you will be given a consultation beforehand to see if it is appropriate for you.
The vast majority of men get the results they want from Tadalafil – the ability to get a strong erection for up to 36 hours. As with all PDE5 inhibitors, you still need sexual stimulation for the drug to do its thing, so light some candles, put on some Barry White, and get your game face on. It’s go time!

Using Tadalafil (Cialis) to treat Erectile Dysfunction

Tadalafil is the name of the active ingredient in both generic Tadalafil and branded Cialis tablets, so they work in the same way. You can check out the differences in our blog article, Tadalafil vs. Cialis, but as they are essentially the same drug, you will need a prescription for both Cialis or Tadalafil in the UK.

The main difference between Tadalafil and Cialis is the price. In the UK, branded Cialis is priced around £38 for four 10mg tablets. That equates to about £9.50 per tablet. At Manual, Tadalafil is available from £3 per tablet for the same dosage.

The normal dose of Tadalafil is 10mg, which has the desired effect in the vast majority of men who are experiencing erectile dysfunction. There are also 2.5mg and 5mg variants, which are taken once daily. These are recommended for individuals with a more active sex life – perhaps 3 times per week or more. At Manual, we offer the 2.5mg once daily variant, as well as the 10mg standard dose.

As 10mg Tadalafil is designed to last 36 hours, you don’t need to take it daily. And we recommend that you only take it when you need it. As stated, the lower-dose versions of the drug (2.5mg and 5mg) can be taken daily, but this isn’t the most typical approach for those men who use Tadalafil.

What are the side effects of Tadalafil?

Side effects are rare with Tadalafil, but when they do occur, the most common ones are headaches, flushing, dyspepsia (indigestion), nasal congestion, dizziness, nausea, muscle aches, hot flush, and vision changes (such as having a blue color tinge or blurred vision).

Very occasionally, more serious side effects such as sudden hearing loss or Priapism (unwanted prolonged erection for 4 hours or more) have been reported with Tadalafil usage. The likelihood of a serious side effect increases if the Tadalafil is mixed with drinking excessive alcohol, grapefruit juice, or also due to drug interactions with medications containing nitrates.

Nitrates are found in medications for high blood pressure and heart disease. They work by widening your blood vessels so that your blood pressure decreases. However, Tadalafil does the same thing – and their combination can result in serious – potentially fatal – drops in blood pressure.

Please read the patient information leaflet carefully for a full list of side effects and advice. Seek medical attention if you develop serious side effects after taking Tadalafil.

Who should not take Tadalafil?

Women, men without erectile dysfunction, and anyone under the age of 18 should never take Tadalafil – or any other ED drug for that matter.

Men whose doctor has advised that they’re not fit enough for any physical or sexual activity, due to a recent heart attack, acute myocardial infarction (AMI), or stroke should also be cautious and avoid taking Tadalafil. Similarly, men who have low blood pressure or uncontrolled high blood pressure, pulmonary arterial hypertension, or who have had, or are under treatment for heart problems, angina (chest pain), or any blood flow issues shouldn’t use Tadalafil.

Seek guidance from your GP if you’re currently taking nitrates (nicorandil or other nitric oxide donors e.g. glyceryl trinitrate, isosorbide mononitrate or isosorbide dinitrate), or any of the following: recreational drugs such as ‘poppers’ (amyl nitrite); riociguat or other guanylate cyclase stimulators; ritonavir; CYP3A4 inhibitors, e.g. saquinavir; cimetidine; itraconazole or ketoconazole; erythromycin or rifampicin; diltiazem; alpha-blockers, such as alfuzosin; doxazosin or tamsulosin, which are medicines to treat urinary problems due to enlarged prostate (benign prostatic hyperplasia) or to treat high blood pressure

Men with hypersensitivity to the active substance or any of the excipients, anatomical deformation of the penis (such as angulation, cavernosal fibrosis, or Peyronie’s disease), or any serious health condition should discuss their condition fully with their doctor before seeking Tadalafil treatment

Alternatives to Cialis (Tadalafil)?

Tadalafil is one of several PDE5 inhibitors that can be used to treat erectile dysfunction. Sildenafil, (Viagra), is a popular alternative to Tadalafil which isn’t as long-lasting. Vardenafil (Levitra) and Avanafil (Spedra) are also less widely-used PDE5 enzyme inhibitors that treat ED. If you’re not sure, talk to one of the clinicians at Manual, who will provide expert advice and personalised treatment solutions.