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Cialis is an effective treatment for male sexual dysfunction. The main active component of the drug is tadalafil. It is absorbed quickly enough, giving a positive result. The rate of uptake depends on the type of foods used. Fatty foods and alcohol reduce drug effectiveness, but the time of administration does not affect the speed and degree of absorption.
Mechanism of action
Tadalafil directly acts on penile smooth muscles, relaxing it and improving blood flow. A man is able to have sexual intercourse for a longer time, feelings are aggravated, intimate life is getting better, complexes are leaving. The effect of Cialis use occurs 16 minutes and lasts for 36 hours. The drug promotes an erection without affecting the brain.
Cialis provides:
- hypersensitivity during sex;
- strong erection for several hours;
- quick recovery after orgasm.
According to statistics, every 1/3 man faces problems with erection. Sexual dysfunction directly affects the quality of not only an intimate life but also, in general, on the male psyche. A man who is not able to satisfy a woman’s needs begins to complicated mental problems, depression appears. It even comes to the fact that a person begins to avoid sexual intercourse.
Solving the problem of poor erection is quite easy and simple. Cialis is created specifically to increase male strength, treat sexual dysfunction and improve the quality of intimate life.
Dosage and administration
Oral administration. The use of Cialis is intended for erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency is daily, 5 mg once a day, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity.
For patients with infrequent sexual activity (less than 2 times a week): it is recommended to prescribe Cialis in a dose of 20 mg, immediately before sexual activity, according to the instructions for use. The maximum daily dose of Cialis is 20 mg.
Overdose
Symptoms: undesirable effects were the same as when using the drug in lower doses with single administration tadalafil to healthy individuals, in a dose of up to 500 mg and in patients with erectile dysfunction, repeatedly up to 100 mg/day. Treatment: in case of an overdose, standard symptomatic treatment is prescribed. With hemodialysis, tadalafil is practically not excreted.
Contraindications
- Hypersensitivity to tadalafil or any drug substance;
- Taking preparations containing any organic nitrates;
- Use in people under 18 years of age;
- The presence of contraindications to sexual activity in patients with CVD diseases (myocardial infarction during the last 90 days, unstable angina, the occurrence of an attack of angina pectoris during intercourse, chronic heart failure II-IV classes according to NYHA classification, uncontrolled arrhythmias, arterial hypotension (blood pressure less than 90 / 50 mmHg), uncontrolled arterial hypertension, ischemic stroke over the past 6 months);
- Loss of vision due to non-arterial anterior ischemic optic neuropathy (regardless of association with PDE-5 inhibitors);
- The simultaneous doxazosin administration, as well as drugs for the treatment of erectile dysfunction;
- Frequent (more than 2 times a week) use in patients with chronic renal failure (Cl creatinine
- Lactase deficiency, lactose intolerance, glucose-galactose malabsorption.
Side effects
- Immune system: infrequently – hypersensitivity reactions.
- Nervous system: very often – headache; often – dizziness; seldom – a stroke (including acute cerebrovascular accident of the hemorrhagic type), fainting, transient ischemic attacks, migraine, epileptic seizure, transient amnesia.
- Organs of vision: infrequently – blurred visual perception, eyeball pain; rarely – visual field disturbance, swelling of the eyelids, injection of vessels of the sclera of the eyeball, non-arterial anterior ischemic optic neuropathy, retinal vascular occlusion.
- Hearing organ and labyrinth disorders: rarely – sudden hearing loss.
- Cardiovascular system: infrequently – a feeling of palpitations, tachycardia, decreased blood pressure (in patients who have already taken antihypertensive drugs), increased blood pressure; rarely – myocardial infarction, ventricular arrhythmias, unstable angina.
- Respiratory system: infrequently – nasal congestion, shortness of breath; rarely – nosebleeds.
- Gastrointestinal tract: often – dyspepsia; infrequently – abdominal pain, gastroesophageal reflux.
- Skin and subcutaneous tissues: infrequently – rash, hyperhidrosis (excessive sweating); rarely – urticaria, Stevens-Johnson syndrome, exfoliative dermatitis.
- Musculoskeletal and connective tissue: often – back pain, myalgia.
- Genitals and mammary gland: rarely – prolonged erection, priapism.
- General disorders: infrequently – chest pain; rarely – facial edema, sudden cardiac death.
Interactions
- Tadalafil is mainly metabolized by the CYP3A4 enzyme. The selective inhibitor of CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. ;
- Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and itraconazole, increase tadalafil activity. ;
- With the simultaneous administration of an antacid (magnesium hydroxide/aluminum hydroxide) and tadalafil, the absorption rate of the latter decreases without changing its AUC. ;
- Tadalafil enhances the hypotensive effect of nitrates. This occurs as a result of the additive effect of nitrates and tadalafil on the metabolism of nitric oxide and cGMP. Therefore, the use of tadalafil in patients receiving nitrates is contraindicated.
Benefits
- Effective for 36 hours;
- It works only in the presence of stimulation and excitement;
- Cialis enhances the pleasure of sexual intercourse due to the influx of blood into the pelvic organs;
- A minimal list of side effects that are extremely rare;
- Quick result (occurs 15-20 minutes after application);
- Easy therapeutic effect;
- Does not affect sperm;
- It can be used together with alcohol;
- It improves the psychological state of men;
- The best price.
