Introduction The dietary supplement market, once synonymous with herbal teas and vitamin capsules, has expanded into a multi-billion-dollar industry that thrives on promises of vitality, enhanced performance, and well-being. Unfortunately, this growth has been accompanied by a troubling phenomenon—the illegal…
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Erectile Dysfunction Medications
The clinical puzzle that sent us back to the placenta Obstetricians do not prescribe phosphodiesterase-5 (PDE-5) inhibitors to make headlines; they do it because uteroplacental perfusion can make or break a pregnancy. Fetoplacental hypoperfusion sits at the root of fetal…
Why a PDE-5 inhibitor belongs on the skin On first pass, putting tadalafil—a phosphodiesterase type 5 (PDE-5) inhibitor better known from urology clinics—onto an open wound sounds eccentric. On second pass, it is biochemistry 101. PDE-5 inhibition elevates cyclic GMP,…
Understanding Age-Related Macular Degeneration: An Introduction to the Silent Vision Thief Age-related macular degeneration (AMD) silently and progressively steals vision, primarily affecting older adults and significantly impacting quality of life. AMD is currently recognized as the leading cause of irreversible…
Facing the Challenges of Distal Ureteral Stones Distal ureteral stones represent a frequent urological emergency, significantly impacting patients’ quality of life. While smaller stones often pass spontaneously, stones sized between 5 and 10 mm present a substantial challenge due to…
A Deeper Look at Anti-MDA5 Dermatomyositis and Its Challenges Dermatomyositis (DM) represents a unique spectrum of autoimmune disorders primarily characterized by inflammation affecting muscles and skin. One subtype, identified by the presence of anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibodies, particularly…
The Complexity of Pulmonary Arterial Hypertension Treatment Pulmonary arterial hypertension (PAH) remains a formidable clinical challenge characterized by progressive vasoconstriction and vascular remodeling, severely impairing the patient’s quality of life. Therapeutic advancements, notably the combination of tadalafil, a phosphodiesterase type-5…
The Challenging Landscape of Tadalafil Administration Tadalafil, widely known under the brand Cialis®, has garnered acclaim for its effective treatment of erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension (PAH). Lauded for its notably extended half-life—approximately 14-15…
Radical prostatectomy (RP) remains a fundamental treatment for localized prostate cancer, offering favorable oncological outcomes for countless patients each year. Despite advancements in surgical techniques such as nerve-sparing procedures and robotic assistance, postoperative complications remain prevalent, notably erectile dysfunction (ED)…
Age-related macular degeneration (AMD) is a degenerative eye disease prevalent among the elderly, leading to irreversible vision loss in advanced stages. As populations age globally, AMD has emerged as a significant public health concern, demanding ongoing research into innovative treatments….
Wound healing is an intricate biological process essential for the maintenance and restoration of skin integrity. The skin is not merely a superficial barrier; it plays a critical role in temperature regulation, hydration balance, and defense against environmental threats such…
Introduction: Understanding Anti-MDA5 Dermatomyositis and Its Challenges Dermatomyositis (DM) is an autoimmune disease characterized by muscle inflammation, weakness, and distinctive skin manifestations. Among its subtypes, the form associated with antibodies against melanoma differentiation-associated gene 5 (anti-MDA5 DM) stands out due…
BackgroundFor low- and intermediate-risk pulmonary arterial hypertension (PAH), guidelines favor dual therapy with an endothelin-receptor antagonist (ERA) plus a phosphodiesterase-5 inhibitor (PDE5i). A once-daily fixed-dose macitentan 10 mg/tadalafil 40 mg tablet could cut pill burden and boost adherence. ObjectivesA DUE,…
Understanding Persistent Storage Symptoms in Benign Prostatic Hyperplasia Benign prostatic hyperplasia (BPH) is one of the most common urological conditions affecting men aged 50 years and above. While often discussed with polite discomfort in public, this condition significantly impacts men’s…
Introduction Benign prostatic hyperplasia (BPH) affects millions of men worldwide, particularly those aged over 50. Although benign, the symptoms associated with BPH significantly impact quality of life, notably through sexual dysfunction and bothersome lower urinary tract symptoms (LUTS), such as…
Understanding Prostate Brachytherapy and Its Common Side Effects Prostate brachytherapy (PB), particularly low-dose rate (LDR) treatment using iodine-125 seeds, has become a highly effective method for treating localized prostate cancer (PCa). This minimally invasive approach delivers precise radiation directly into…
In recent years, there has been increasing awareness of how comorbidities—conditions like hypertension and diabetes that exist alongside primary illnesses—significantly impact cancer outcomes, particularly among Black individuals. Despite advancements in healthcare, Black cancer patients in the United States continue to…
Ananias C. Diokno, Avaneesh Kunta, Ryan Bowen Oakland University William Beaumont School of Medicine, Rochester, MI, United States of America University of Central Florida College of Medicine (UCF COM), Orlando, FL, United States of America Historical Perspectives: Testosterone and the Discovery of Leydig Cells Historically,…
The Significance of Combined Therapy in Pulmonary Arterial Hypertension (PAH) Pulmonary arterial hypertension (PAH) is a severe and progressive disease characterized by high blood pressure in the pulmonary arteries, which ultimately leads to heart failure if left untreated. Modern therapeutic…
The Keto Craze and Lipid Anomalies Ketogenic diets (KD), famed for their weight-loss potential and metabolic health benefits, have surged beyond mere obesity and diabetes management. Today, their applications span neurological disorders, inflammatory conditions, and even mental health treatments. Yet,…